SHENYF 4-12/20/32mm 6-30mm HSS Cobalt Step Cone Drill Bit Nitride Coated Wood/Metal Hole Cutter Drill Spiral Groove Step Drill Bit Most Trustworthy (Color : 3pcs Set with Bag)

hot limited edition Stair Banister Balcony Net Cover Cargo Duty Heavy Net Safety Child Climbing House Tree QINLMITE Protection 10ft)) * 3m(7 * 2 : (Size Net Decor Railing Playground Net Baby Products

Author affiliations

hot limited edition Stair Banister Balcony Net Cover Cargo Duty Heavy Net Safety Child Climbing House Tree QINLMITE Protection 10ft)) * 3m(7 * 2 : (Size Net Decor Railing Playground Net Baby Products

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

hot limited edition Stair Banister Balcony Net Cover Cargo Duty Heavy Net Safety Child Climbing House Tree QINLMITE Protection 10ft)) * 3m(7 * 2 : (Size Net Decor Railing Playground Net Baby Products

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
12" Memory Foam Mattress Gel Memory Foam Mattress in A Box King Size Softness Bed Mattress for Supportive Pressure Relief & Cooler Sleeping -King

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the United Scientific Supplies 33303-BULK Narrow Mouth Reagent Bottle, 250mL Capacity, Polypropylene, Bulk (Pack of 250).

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Urrea 5003B 3/8-Inch Drive Chrome Socket Set, 28-Piece provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Cotton Kimono Printed Kimono Robe Wear Soft And Comfortable Bathrobes Kimono, Wrap Dress, Hen Party Wear A Great Gift For Her By VISHWAKARMAS HANDICRAFT.

Read more about Innovations 288-3W-BAB-G73 Three Light Bath Vanity from Nouveau 2 Collection.

Standard Motor Products DS-2312 Power Window Switch

Social activity

Spotlight

Advertisements