Ampco Safety Tools DWI-3/4D2-3/16 Socket, Deep Well Impact, Non-Sparking, Non-Magnetic, Corrosion Resistant, 3/4" Drive, 2-3/16"

up to 60% discount Standard Plug TCP91F Products Motor Automotive

Author affiliations

up to 60% discount Standard Plug TCP91F Products Motor Automotive

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

up to 60% discount Standard Plug TCP91F Products Motor Automotive

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Jed North Men's Slim Fitted Stretchy Denim Pants Skinny Fit Ripped Distress Workout Performance Casual Jeans

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the MiracleLED 604143 Home Makeover Combo Pack (6 Pack), Yellow,White.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are DEPO 373-1124L-AS Replacement Driver Side Headlight Assembly (This product is an aftermarket product. It is not created or sold by the OE car company) provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Kurt Geiger London Violet Horizontal Tote.

Read more about Cardoctor 5WK9 7341A Nitrogen Oxide Sensor Nox Sensor Catalyst Lambda A0101531928 EA0101531928 Fits Detroit Diesel Fits Benz (A0101531928/5WK9 7341A, Nox Sensor).

Wemaliyzd Men's Notch Lapel 2 Piece Prom Party Suits 1 Button Blazer Jacket Pants

Social activity

Spotlight

Advertisements