Adult Travel Umbrella Structure Brown Abstract Windproof Kids Travel Umbrella Girl Rain & Wind Resistant Compact And Lightweight For Business And Travels

professional integrated online shopping mall R&M Richards 18W Red Jumpsuit Asymmetric Shoulder One Plus Womens Woman Clothing, Shoes & Jewelry

Author affiliations

professional integrated online shopping mall R&M Richards 18W Red Jumpsuit Asymmetric Shoulder One Plus Womens Woman Clothing, Shoes & Jewelry

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

professional integrated online shopping mall R&M Richards 18W Red Jumpsuit Asymmetric Shoulder One Plus Womens Woman Clothing, Shoes & Jewelry

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
GMQNBXN Womens One Piece Solid Color Jumpsuits Snowsuits Snowboard Ski Suit Winter Outdoor Waterproof for Snow Sports

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Bullard 61DGP Standard Series Cap Style Hard Hat, 4 Point Pin Lock Suspension, Cotton Brow Pad, Dove Grey, One Size.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are YZZSJC Large Capacity Lunch Bag Insulated Canvas Food Bag Tote Picnic Thermal Cooler Bags Women Lunch Box Insulated Picnic Lunch Bag Insulated Lunch Bag provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Haoge LH-X50 Bayonet Square Metal Lens Hood for Fujifilm Fuji Fujinon XF 50mm F2 R WR Lens on X-Pro2 X-Pro1 X-T2 X-T1 X-T20 X-T10 X-E2S X-A5 X-A20 X-E3 X-H1.

Read more about Motorcycle PWK Carburetor 34mm Carb 2T 4T Engine for Dirt Bike Motorcycle Scooter ATV Quad.

EFFY 925 STERLING SILVER FRESH WATER PEARL EARRINGS

Social activity

Spotlight

Advertisements