Metal Model Car for Volkswagen Golf GOIF GTI Simulation Alloy Car Model Ornament 1/18 Color Toy Car

buy cheap Wooden Stand Monitor Monitor TV(Black) Office Home for Rack Bracket Display Stand Electronics

Author affiliations

buy cheap Wooden Stand Monitor Monitor TV(Black) Office Home for Rack Bracket Display Stand Electronics

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

buy cheap Wooden Stand Monitor Monitor TV(Black) Office Home for Rack Bracket Display Stand Electronics

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Rembrandt Charms 07 Babyshoe July Charm Pendant Available in Gold or Sterling Silver

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the RockShox Fork Lower Leg Dust Seal Installation Tool 32mm (for flangeless and flanged dust Seals).

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Womens 7XL Thick Faux Fur Coat Big Hooded Parka Overcoat Winter Long Sleeve Coat Jacket provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the 1950 Women Vintage Cocktail Dress Summer Tea Party Retro Rockabilly Prom Dresses Cap-Sleeve Blue Flower M.

Read more about Cardone 13-3466 New Brake Master Cylinder.

Folding Bike Locks Heavy Duty Anti Theft Bike Chain Lock Alloy Steel Strong Bicycle Lock Foldable with Mounting Bracket with 3 Keys 85cm/33in Long

Social activity

Spotlight

Advertisements