Kerrits Elevation Coat

hot sale online and Durable Capacity Large Fashion Purse, Satchel Handle Top Tote Handbag Bag Shoulder Leather PU Waterproof, Pattern Lemon Travel, and Shopping Work Women's for Clothing, Shoes & Jewelry

Author affiliations

hot sale online and Durable Capacity Large Fashion Purse, Satchel Handle Top Tote Handbag Bag Shoulder Leather PU Waterproof, Pattern Lemon Travel, and Shopping Work Women's for Clothing, Shoes & Jewelry

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

hot sale online and Durable Capacity Large Fashion Purse, Satchel Handle Top Tote Handbag Bag Shoulder Leather PU Waterproof, Pattern Lemon Travel, and Shopping Work Women's for Clothing, Shoes & Jewelry

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Instarry 5D Diamond Painting Large Size Full Drill Cherry Blossom Cross Stitch Mosaic Home Decorations for Living Room Art Kit 59.1x19.7 inch

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Pertronix 1742LSCC Ignitor (Hitachi # D4B880-01).

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Liftall EN1803DX13 Polyester Web Endless Sling, 1-ply, 3" x 13' provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the M6 M8 Hanger Bolts Double Ended Thread Lag Screws Wood Screws Furniture Fixing Self Tapping Screws Color Zinc Plated (50,M8x90mm).

Read more about Mizuno Men's Football Shoe.

KNS Accessories KC3019R 1967 Chevrolet Car Outside Door Mirror for Passenger Side

Social activity

Spotlight

Advertisements