Mepra AZC10881123 Salad Fork Serving Due Oro, Gold

online shopping and fashion store UX/RD 30126 Centaur Style ER16 Nut, E for Spanner Industrial & Scientific

Author affiliations

online shopping and fashion store UX/RD 30126 Centaur Style ER16 Nut, E for Spanner Industrial & Scientific

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

online shopping and fashion store UX/RD 30126 Centaur Style ER16 Nut, E for Spanner Industrial & Scientific

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Rimi Hanger Womens Fine Knit Tracksuit Ladies Round Neck Top Trouser 2pcs Co Ord Loungewear Small/Large

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the SKM Wall Shelf High Gloss Gray 17.7"x6.2"x17.7" Chipboard.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Worldwide Electric 2WTBK-1.1116 Shaft Mount Reducer Accessories, Tapered Bushing Kits, Box Size 2, 1-11/16" Bushing Size provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Solar Lights Outdoor, Solar Garden Lights -- 2 Pcs Solar Pineapple Lantern Outdoor Garden Hanging Tree Lights Solar Powered Spiriallights Warm White Handhold Garden Decoration Lighting.

Read more about City Tycoon Board Game.

The Wizard Of Oz - Emerald City Opoly

Social activity

Spotlight

Advertisements