Fenner Drives L04OG858M Eagle Round Belt 85, Non-Reinforced, 8 mm, 30.5 m Overall Length, Polyurethane, Orange

discount sale Number, Cutter 1 Angle, Pressure Degree 1/2 14 Relieved, Form Steel, Speed High Cutter, Milling Gear Involute 12917 Company Tool F&D 8" Diameter 1/4" 3 Size, Hole 1/4" 1 Pitch, Diametrical Industrial & Scientific

Author affiliations

discount sale Number, Cutter 1 Angle, Pressure Degree 1/2 14 Relieved, Form Steel, Speed High Cutter, Milling Gear Involute 12917 Company Tool F&D 8" Diameter 1/4" 3 Size, Hole 1/4" 1 Pitch, Diametrical Industrial & Scientific

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

discount sale Number, Cutter 1 Angle, Pressure Degree 1/2 14 Relieved, Form Steel, Speed High Cutter, Milling Gear Involute 12917 Company Tool F&D 8" Diameter 1/4" 3 Size, Hole 1/4" 1 Pitch, Diametrical Industrial & Scientific

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Aeroskin Full Body with Kevlar Knee Pads (Black/Yellow, X-Small)

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Spenco womens Anabel Sandal.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Greenfield Threading 403520 Hexagon Rethreading Die Set, 1/4" - 1/2", Carbon Steel, Uncoated (Bright) Coating, Right Cut, 10-Piece provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the African Couple Wear Women's Maxi Dress Men's Shirt and Pants Set Casual Print Couple Wear 475 12 women2XL/US16.

Read more about Lutema BL-FU220B-L02 Optoma BL-FU220B SP.85F01G001 Replacement DLP/LCD Cinema Projector Lamp, Premium.

Tacwise 0311 90/40 mm Narrow Crown Staples - Box of 5,000

Social activity

Spotlight

Advertisements