5.11 Tactical Men's Flex-Tac Stryke Class B PDU Short Sleeve Shirt, Teflon Finish, Style 71038

online outlet sale Piergiacomi 8–Piece K 8–1 Set, Tool Electronics Tools & Home Improvement

Author affiliations

online outlet sale Piergiacomi 8–Piece K 8–1 Set, Tool Electronics Tools & Home Improvement

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

online outlet sale Piergiacomi 8–Piece K 8–1 Set, Tool Electronics Tools & Home Improvement

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Bosch 13111 Oxygen Sensor, OE Fitment (Chevrolet, Oldsmobile, Pontiac, Saturn )

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Mishimoto MMHOSE-RAM-98DBK Silicone Radiator Hose Kit Compatible With Dodge Ram Cummins 5.9 1994-2002 Black.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are to My Daughter Gift Blanket from Mom for Birthday, Gift for My Daughter Love Throws Letter Birthday Present, Fuzzy Fleece Blanket with Letter Warm Soft, 50x60 provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Glenna Jean Camo Baby 3pc Set (Includes Quilt, Sheet, Skirt), Pink, Crib.

Read more about EMCCPTU Creative Fingertips Movement Gift Pendant,Beginners' Special Boards,Teenagers' Double Warped Fingertip Skateboards Gift Pendant,A Full Set of Imported Maple Fingertip Skateboards.

YJYDD Microwave Stand 2 Tiers Stainless Steel Microwave Oven Shelf Rack Stand Kitchen Storage Holder Microwave Oven Stand Storage Shelf

Social activity

Spotlight

Advertisements