Canon PowerShot SD1400IS 14.1 MP Digital Camera with 4x Wide Angle Optical Image Stabilized Zoom and 2.7-Inch LCD (Orange)

wholesale price Welcome Outdoor or Rug Indoor Mat, Door Scene Kitchen Tzu Shih White Red CK7791JMAT Treasures Caroline's Mat Multicolor 36W, X 24H Doormat, 24x36 Patio, Lawn & Garden

Author affiliations

wholesale price Welcome Outdoor or Rug Indoor Mat, Door Scene Kitchen Tzu Shih White Red CK7791JMAT Treasures Caroline's Mat Multicolor 36W, X 24H Doormat, 24x36 Patio, Lawn & Garden

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

wholesale price Welcome Outdoor or Rug Indoor Mat, Door Scene Kitchen Tzu Shih White Red CK7791JMAT Treasures Caroline's Mat Multicolor 36W, X 24H Doormat, 24x36 Patio, Lawn & Garden

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
WAYDERNS Women's Thick Patent Leather Pointed Toe Slingback Ankle Strap Block High Heel Pumps Shoes 3 Inch

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the AquaPlants 6 x Cup in VITRO of Cryptocoryne, Cryptocoryne Mix, Different Types for Fish Tank.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Crimping Pliers set YF-04B 8 jaw for 2.8 4.8 6.3 VH3.96/Tube/Insulation/Coaxial cable Terminals Multifunctional Electrical tools provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the HHIP 3900-5350 Mini Aluminum Quick Change Tool Post and Holder Kit.

Read more about PICNIC TIME Brown Cleveland Browns Pilsner Beer Gift Set for 2.

KEEPWORD WiFi IP Cloud GSM Tuya Wireless Intelligent Home Office Security Alarm Burglar Anti-Theft System,RFID Access,Auto Dialer,Touch Keypad

Social activity

Spotlight

Advertisements