Corral Boots Girl's A2980 (Little Kid/Big Kid) Brown/Bone 4.5 Big Kid M

100% fit guarantee EU Suede Resin Fastc7 Clergerie 36.5 M 6) Women's (US Clothing, Shoes & Jewelry

Author affiliations

100% fit guarantee EU Suede Resin Fastc7 Clergerie 36.5 M 6) Women's (US Clothing, Shoes & Jewelry

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

100% fit guarantee EU Suede Resin Fastc7 Clergerie 36.5 M 6) Women's (US Clothing, Shoes & Jewelry

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Innovations 516-1P-AB-G249-LED Transitional LED Mini Pendant from Ballston Collection in Brass - Antique Finish

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Atrend 15SPLDV 15 Dual Vented SPL High Grade MDF Subwoofer/Speaker Enclosure Subwoofer Box Designed and Engineered In USA With The Latest In Computer Automated Design So You Can Let The Music Move You.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Altra Men's AL0A4VQA Escalante 2.5 Road Running Shoe, Dark Slate - 8 M US provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Killer Filter Replacement for WIX D52A125TBV.

Read more about Mariana Black Orchid Silver Plated Flower Crystal Tennis Bracelet, 8".

92 Qt. / 23 Gallon / 87 Liters Blue Slim Rectangular Recycling Can and Blue Lid with Holes. Trash Bin Kitchen Trash Can Recycling Bins Plastic Bin Garbage Can.

Social activity

Spotlight

Advertisements