Luber-finer G6335-12PK Fuel Filter, 12 Pack

discount sales (F2P23UT) G1 840 ELITEBOOK HP-Compaq 14.0" HD WXGA Panel Display Screen LED LCD Electronics

Author affiliations

discount sales (F2P23UT) G1 840 ELITEBOOK HP-Compaq 14.0" HD WXGA Panel Display Screen LED LCD Electronics

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

discount sales (F2P23UT) G1 840 ELITEBOOK HP-Compaq 14.0" HD WXGA Panel Display Screen LED LCD Electronics

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
LED Shower Head 3 Color Changing Handheld Shower Heads with Digital Temperature Fahrenheit Display Water Powered LED Hand Shower 3 Spraying Mode , Male Thread G1/2 (Fahrenheit)

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the SKF 160-1CX10FT (ANSI) Cottered Roller Chain.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are 14k White Gold Diamond Heart Bracelet for Women, Love Jewelry for Wife / Girlfriend, Gifts for Her, 6.8-8.4 Inch provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the NBK MJC-55-ERD-7/16-12 Jaw Flexible Coupling, Set Screw Type, Bore Diameters 7/16" and 12 mm, Aluminum A2017.

Read more about American Shifter 399837 Shifter Kit (4L60E 8" Trim Kit Dipstick For D5E75, 1 Pack).

XBDD Black Coffee Table Share w/Pets Environment-Friendly Wooden Tabletop TeaTable L46*W23.6*H18.2

Social activity

Spotlight

Advertisements