John Boos Block BWC-3 Butcher Block Board Cream, 5 ounce (Pack of 3)

the best online store offer Carve Havana Polarized Translucent/Green Grey - Sunglasses Clothing, Shoes & Jewelry

Author affiliations

the best online store offer Carve Havana Polarized Translucent/Green Grey - Sunglasses Clothing, Shoes & Jewelry

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

the best online store offer Carve Havana Polarized Translucent/Green Grey - Sunglasses Clothing, Shoes & Jewelry

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Obermeyer Kids Molten Mitten (Little Kids/Big Kids)

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the COMP Cams 8414-12 Hi-Tech 7.950" Long.105" Wall, 5/16" Diameter Pushrod Set of 12.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are JCS1487T TRW Coil Spring Set Lincoln Town Car: 1986-1989 Front provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Style & Co. Womens Super-Skinny Brushed Ankle Jeans, Rhone, Size 12.

Read more about Freya Women's Soiree Lace High Apex Bra.

INTERESTPRINT Tropical Palm Leaves and Exotic Flowers Womens Top Handle PU Leather Shoulder Satchel Bag

Social activity

Spotlight

Advertisements