Conical Fabric Lampshade Diameter 55 x 28 x 35 cm Beige/Pink

quality guaranteed Irwin Tools 73132 1/2-Inch Turbomax Jobber Length, 6-Pack Power & Hand Tools

Author affiliations

quality guaranteed Irwin Tools 73132 1/2-Inch Turbomax Jobber Length, 6-Pack Power & Hand Tools

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

quality guaranteed Irwin Tools 73132 1/2-Inch Turbomax Jobber Length, 6-Pack Power & Hand Tools

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Topline C1204 Acorn Lug Nut - 2 Piece

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Minuteman International SS-31 Twisted Rope Folding Fireplace Screen.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Elk Lighting 81212/3 Vanity-Lighting-fixtures, Bronze provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Socket, Impact 1D 1-3/4", 8-PT, Non-Sparking, Non-Magnetic, Corrosion Resistant.

Read more about Goldbuch Bella Vista Spiral Album Linen 35 x 30 cm Pink.

New All Balls EZ Start Carburetor Rebuild kit (46-8083) Compatible with/Replacement For Polaris Magnum 325 2x4 2000-2002, Magnum 325 4x4 HDS 2002, Magnum 325 4x4 HDS FB 2001, Trail Boss 325 2000-2002

Social activity

Spotlight

Advertisements