Southeast Tool SE04010-14 TG100 Collet, 1/4" ID, 2.36" Length

credit guarantee Series MWS MWS1010X20DB Materials Mitsubishi Solid Dia. Shank mm 11 Length, Point mm 1.8 Dia, Cutting mm 10.1 Depth, Hole mm 20 Coolant, Internal Drill, Carbide Industrial & Scientific

Author affiliations

credit guarantee Series MWS MWS1010X20DB Materials Mitsubishi Solid Dia. Shank mm 11 Length, Point mm 1.8 Dia, Cutting mm 10.1 Depth, Hole mm 20 Coolant, Internal Drill, Carbide Industrial & Scientific

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

credit guarantee Series MWS MWS1010X20DB Materials Mitsubishi Solid Dia. Shank mm 11 Length, Point mm 1.8 Dia, Cutting mm 10.1 Depth, Hole mm 20 Coolant, Internal Drill, Carbide Industrial & Scientific

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
KYB 340011 Excel-G Gas Strut

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Moen 8137 Commercial M-Dura Single-Handle Multi-Purpose Faucet with Spout 2.2 gpm, Chrome.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Rugged and Easy Fitting Intake Manifold Gasket Set - Compatible with 4.8L 5.3L 6.0L Chevy Silverado, Suburban, Tahoe, GMC Sierra, Yukon, Savana, Cadillac Escalade - Replace 89060413 MS98016T provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Exsiqute Womens Platform Wedge Sandals Open Toe Ankle Strap Casual Summer Dress Espadrilles Wedge Sandals For Women.

Read more about Timex Men's Waterbury Stainless Steel Quartz Watch with Leather Strap, Brown, 19 (Model: TWF3C8270).

COMP Cams 2901-16 Performance Series EDM Solid Lifter Set AMC, Chrysler 273-360, 383-440/426 HEMI

Social activity

Spotlight

Advertisements