Allied Brass WM-5T/3X-ORB 8 Inch Wall Mounted 3X Magnification Make-Up Mirror, Oil Rubbed Bronze

free and fast delivery available box storage Watch 1pc man Organiser Collection Box Watch Jewelry Box Watch Wood Solid Box Storage Practical Durable Clothing, Shoes & Jewelry

Author affiliations

free and fast delivery available box storage Watch 1pc man Organiser Collection Box Watch Jewelry Box Watch Wood Solid Box Storage Practical Durable Clothing, Shoes & Jewelry

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

free and fast delivery available box storage Watch 1pc man Organiser Collection Box Watch Jewelry Box Watch Wood Solid Box Storage Practical Durable Clothing, Shoes & Jewelry

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
MYYINGBIN 30Cm Tagine Pot with Enameled Cast Iron Base Cone-Shaped Lid and Anti-Hot Silicone Gloves Housewarming Gift, Pink

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Centaur 402-524 RTX 40 Ultra Precision Collet, 27/32" Diameter.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Dooney & Bourke Florentine Small Satchel, Chestnut/Self Trim provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Lorpen unisex T3+ Ski Polartec Warm Active Socks.

Read more about Lunati 8051-16 Signature Series 7.600" Long 3/8" Diameter Pushrod Set of 16.

StopTech (83.188.6D00.73) Brake Rotor, Front

Social activity

Spotlight

Advertisements