ZHJING Brown Watch Box Jewelry Watches Store Cufflinks Watch Cushion Display Box

lowest whole network Stehle 50512106 Profile 15 AR R L 2 + = Z HM Bit Router Industrial & Scientific

Author affiliations

lowest whole network Stehle 50512106 Profile 15 AR R L 2 + = Z HM Bit Router Industrial & Scientific

In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions. Little is understood about how the physical properties of the mucosal glycocalyx influence molecular recognition at the cellular boundary. Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx. We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells. The extended glycocalyx provided protection against agglutination of RBCs by both lectins; however, the rate and magnitude of ConA binding were attenuated to a greater degree in the presence of the glycopolymer spectators compared to those measured for SNA. The different sensitivity of ConA and SNA to glycocalyx crowding likely arises from the distinct presentation of their mannoside and sialoside receptors, respectively, within the native RBC glycocalyx.

lowest whole network Stehle 50512106 Profile 15 AR R L 2 + = Z HM Bit Router Industrial & Scientific

Article type
Paper
Submitted
28 Feb 2019
Accepted
10 Apr 2019
First published
Fridge Dust Cover with Pockets, Valentine Gnome Microwave Oven Dustproof Cover Decorative Kitchen Appliance Protector Cover Multi-Purpose Top Covers 28"x67" You Need is Love Burlap Backdrop

Faraday Discuss., 2019,219, 138-153

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

D. J. Honigfort, M. H. Zhang, S. Verespy and K. Godula, Faraday Discuss., 2019, 219, 138 DOI: 10.1039/C9FD00024K

To request permission to reproduce material from this article, please go to the Steelmax SM-AC-1625-2 Annular Cutter, HSS, 1-5/8" Diameter x 2" Depth of Cut.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are Xolyete Simulation Van Transport Truck Toy with Cargo Box Inertial Power Engineering Vehicle Model Children’s Outdoor Activities Personally Interactive Toy Car Gift Can Open Boy Toy Car provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the ST 23220048 Suspension Kit.

Read more about ACDelco Professional 36-348709 Steering Gear Pinion Shaft Seal Kit.

QINLMITE Kids Safety Net, Woven Ceiling Hang Decoration Net Stair Net Heavy Duty Cargo Rope Balcony Railing Protection Net (Size : 1 * 9m(3 * 29ft))

Social activity

Spotlight

Advertisements